Pyruvate Kinase Deficiency Animation

A world first in depicting the full glycolytic pathway using detailed 3D animation.

This mode-of-action animation explains a rare hemolytic disease, called Pyruvate Kinase Deficiency or PK deficiency — created and produced for a biotech team that develops novel therapeutics for rare diseases and cancers via metabolic intervention.


3D Animations (US + Global Markets)
High-Resolution Images


Agios Pharmaceuticals

  • PARP Pyruvate Kinase Deficiency Animation

Our objectives are to visualize the pathophysiology, the current state of supportive care and addressing the unmet need in understanding the root cause of the disease, as well as highlighting the possible treatment for PK deficiency.

Pyruvate Kinase Deficiency Animation
Pyruvate Kinase Deficiency Animation

What is Pyruvate Kinase Deficiency

Pyruvate kinase deficiency is an inherited lack of the enzyme pyruvate kinase (PK), which is used by red blood cells. Without this enzyme, red blood cells break down too easily, resulting in a low level of these cells (hemolytic anemia).

PK deficiency is passed down as an autosomal recessive trait. This means that a child must receive the non-working gene from both parents to develop the disorder.

Pyruvate kinase deficiency is found in people of all ethnic backgrounds. However, certain populations, such as the Amish, are somewhat more likely to develop the condition.


PK Deficiency Animation by Geometric Medical
PK Deficiency Animation by Geometric Medical
PK Deficiency Animation by Geometric Medical

I want to note that the video was a massive success! It was incredibly well received by both Agios employees and physician attendees. One of the "fathers" of PK deficiency, who has published the vast majority of all literature on the disease, came to see the video and was blown away, particularly by the production value and how everything was depicted.

Senior Product Manager, Rare Genetic Disease, Agios Pharma, Massachusetts, USA

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