PARP Inhibition in Breast Cancer Animation

Mechanism-of-action animation exploring the role of PARP inhibitors in breast cancer.

In this animation, we were tasked with explaining the role of Poly(ADP-ribose) polymerase (PARP) inhibitors as a treatment for breast cancer patients with BRCA1 and BRCA2 mutations. We explain how PARP is a protein involved in repairing single-stand breaks in DNA, and inhibition of this enzyme prevents DNA repair, resulting in the accumulation of single-strand breaks.


Oncology Event Animation
Educational Material


Oncology Meeting

  • PARP Inhibition in Breast Cancer Animation
PARP Inhibition in Cancer 3D Animation
PARP Inhibitors in Breast Cancer 3D Animation

During DNA replication, these single-strand breaks lead to double-strand breaks, ultimately resulting in tumour cell apoptosis. PARP inhibitors are most promising in the treatment of breast and ovarian cancers, given relatively high rates of BRCA1/2 mutations in these malignancies.

  • PARP Inhibition in Breast Cancer Animation

What are PARP Inhibitors

PARP helps repair DNA when it becomes damaged. DNA damage may be caused by many things, including exposure to UV light, radiation, certain anticancer drugs, or other substances in the environment.

In cancer treatment, blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. Also called poly (ADP-ribose) polymerase inhibitor.

Reference: NIH - National Cancer Institute

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